| Gene Information | |
|---|---|
| Gene Name | LRP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 770 |
| Protein Names | Low-density lipoprotein receptor-related protein 3 (LRP-3) (105 kDa low-density lipoprotein receptor-related protein) (hLRp105) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000130881 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75074 |
| Gene Card | LRP3 |
| Uniprot ID | O75074 |
| Pfam | PF00431; PF00057 |
| In ASD | no |
| Allosteric Prediction | no (-1.204165906) |
| Ortholog in Animals | Alpaca_ LRP3 ( ortholog_one2one ) Dog_ LRP3 ( ortholog_one2one ) GuineaPig_ LRP3 ( ortholog_one2one ) Macaque_ LRP3 ( ortholog_one2one ) Mouse_ Lrp3 ( ortholog_one2one ) Pig_ LRP3 ( ortholog_one2one ) Rat_ Lrp3 ( ortholog_one2one ) Rabbit_ LRP3 ( ortholog_one2one ) |
| Ohnologs | LRP12, LRP10 |
| Paralogs | LDLR, LRP12, LRP2, EGF, LRP1, VLDLR, LRP4, LRP5, LRP1B, NID2, LRP6, LRP8, LRP10, NID1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte. {ECO:0000269|PubMed:9693042}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3745978 rs3745974 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Membrane, coated pit {ECO:0000250}. |
| Mouse PG classification | NA |
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