Gene Information
Gene NameLRP2
OrganismHomo sapiens (Human)
Gene Length4655
Protein NamesLow-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Target Namelow-density lipoprotein receptor-related protein 2
Target TypeNA
Gene Age645 ( ENSG00000081479 )
Evolutionary StageEumetazoa
AlphaFoldDBNA
Gene CardLRP2
Uniprot IDP98164
PfamPF12662; PF07645; PF00057; PF00058
In ASDno
Allosteric Predictionyes (0.965788984)
Ortholog in AnimalsAlpaca_ LRP2 ( ortholog_one2one )
Dog_ LRP2 ( ortholog_one2one )
Macaque_ LRP2 ( ortholog_one2one )
Mouse_ Lrp2 ( ortholog_one2one )
Pig_ LRP2 ( ortholog_one2one )
Rat_ Lrp2 ( ortholog_one2one )
OhnologsLRP1
ParalogsLDLR, LRP12, EGF, LRP1, VLDLR, LRP4, LRP5, LRP1B, NID2, LRP6, LRP3, LRP8, LRP10, NID1
Tissuekidney
Tissue SpecificityExpressed in first and third trimester cytotrophoblasts in the placenta (at protein level) (PubMed:27798286). Absorptive epithelia, including renal proximal tubules. {ECO:0000269|PubMed:27798286}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2M0P  (NMR  -  ) 
DBSNP rs2229263  rs34693334  rs34291900  rs36082715  rs2302691  rs17848149  rs4667596  rs2228168  rs80338747  rs17848169  rs2228171  rs11674973  rs3213760  rs199583537  rs2075252  rs4667591 
Subcellular location [CC]Apical cell membrane {ECO:0000269|PubMed:23825075, ECO:0000269|PubMed:27798286};
Single-pass type I membrane protein {ECO:0000255}. Endosome lumen {ECO:0000250|UniProtKB:P98158}. Membrane, coated pit {ECO:0000250|UniProtKB:A2ARV4}. Cell projection, dendrite {ECO:0000250|UniProtKB:A2ARV4}. Cell projection, axon {ECO:0000250|UniProtKB:A2ARV4}. Note=Localizes to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, located in the lumen of endosomes as a soluble form. {ECO:0000250|UniProtKB:P98158}.
Mouse PG classificationHPG
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