| Gene Information | |
|---|---|
| Gene Name | LRP12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 859 |
| Protein Names | Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000147650 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y561 |
| Gene Card | LRP12 |
| Uniprot ID | Q9Y561 |
| Pfam | PF00431; PF00057 |
| In ASD | no |
| Allosteric Prediction | no (-0.863154945) |
| Ortholog in Animals | Alpaca_ LRP12 ( ortholog_one2one ) Dog_ LRP12 ( ortholog_one2one ) GuineaPig_ LRP12 ( ortholog_one2one ) Macaque_ LRP12 ( ortholog_one2one ) Mouse_ Lrp12 ( ortholog_one2one ) Pig_ LRP12 ( ortholog_one2one ) Rat_ Lrp12 ( ortholog_one2one ) Rabbit_ LRP12 ( ortholog_one2one ) |
| Ohnologs | LRP3, LRP10 |
| Paralogs | LDLR, LRP2, EGF, LRP1, VLDLR, LRP4, LRP5, LRP1B, NID2, LRP6, LRP3, LRP8, LRP10, NID1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines. {ECO:0000269|PubMed:9927190}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16871494 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:12809483}; Single-pass type I membrane protein {ECO:0000269|PubMed:12809483}. Membrane, coated pit {ECO:0000269|PubMed:12809483}. |
| Mouse PG classification | NA |
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