Gene Information
Gene NameFOXO3
OrganismHomo sapiens (Human)
Gene Length673
Protein NamesForkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000118689 )
Evolutionary StageVertebrata
AlphaFoldDBO43524
Gene CardFOXO3
Uniprot IDO43524
PfamPF00250; PF16676; PF16675
In ASDno
Allosteric Predictionyes (1.160935357)
Ortholog in AnimalsAlpaca_ FOXO3 ( ortholog_one2one )
Dog_ FOXO3 ( ortholog_one2one )
GuineaPig_ FOXO3 ( ortholog_one2one )
Macaque_ FOXO3 ( ortholog_one2one )
Mouse_ Foxo3 ( ortholog_one2one )
Pig_ FOXO3 ( ortholog_one2one )
Rat_ Foxo3 ( ortholog_one2one )
Rabbit_ FOXO3 ( ortholog_one2one )
OhnologsFOXO1, FOXO4, FOXO6
ParalogsFOXO3B, FOXH1, FOXL3, FOXK2, FOXM1, FOXQ1, FOXP3, FOXB2, FOXR1, FOXI2, FOXD2, FOXA2, FOXJ2, FOXD4L1, FOXD4L3, FOXD4L6, FOXD4, FOXD4L5, FOXD4L4, FOXS1, FOXC1, FOXL1, FOXP1, FOXC2, FOXF1, FOXB1, FOXO4, FOXK1, FOXA1, FOXL2, FOXE1, FOXR2, FOXE3, FOXJ3, FOXD1, FOXD3, FOXO1, FOXI3, FOXJ1, FOXO6, FOXA3, FOXN1
TissueNA
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:9479491}.
Pharmacological Animal Models0.131353(Chimpanzee);0.008259(Mouse);0.008126(Rat);0.034146(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2K86  (NMR  -  )  2LQH  (NMR  -  )  2LQI  (NMR  -  )  2UZK  (X-ray  2.70A  )  6MNL  (NMR  -  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:22313691, ECO:0000269|PubMed:22761832, ECO:0000269|PubMed:23283301}. Nucleus {ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:22313691, ECO:0000269|PubMed:22761832, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}. Mitochondrion matrix {ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}. Mitochondrion outer membrane {ECO:0000269|PubMed:29445193};
Peripheral membrane protein {ECO:0000269|PubMed:29445193};
Cytoplasmic side {ECO:0000269|PubMed:29445193}. Note=Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}.
Mouse PG classificationNA
click here to return to the previous page