Gene Information
Gene NameLRP1
OrganismHomo sapiens (Human)
Gene Length4544
Protein NamesProlow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Target Nameprolow-density lipoprotein receptor-related protein 1
Target TypeNA
Gene Age645 ( ENSG00000123384 )
Evolutionary StageEumetazoa
AlphaFoldDBNA
Gene CardLRP1
Uniprot IDQ07954
PfamPF12662; PF16472; PF07645; PF00057; PF00058
In ASDyes
Allosteric Predictionyes (1.017469986)
Ortholog in AnimalsAlpaca_ LRP1 ( ortholog_one2one )
Dog_ LRP1 ( ortholog_one2one )
GuineaPig_ LRP1 ( ortholog_one2one )
Macaque_ LRP1 ( ortholog_one2one )
Mouse_ Lrp1 ( ortholog_one2one )
Rat_ Lrp1 ( ortholog_one2one )
OhnologsLRP2, LRP1B
ParalogsLDLR, LRP12, LRP2, EGF, VLDLR, LRP4, LRP5, LRP1B, NID2, LRP6, LRP3, LRP8, LRP10, NID1
TissueNA
Tissue SpecificityMost abundant in liver, brain and lung.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CR8  (NMR  -  )  1D2L  (NMR  -  )  1J8E  (X-ray  1.85A  )  2FYJ  (NMR  -  )  2FYL  (NMR  -  )  2KNX  (NMR  -  )  2KNY  (NMR  -  ) 
DBSNP rs2306691  rs1800127  rs1207947902  rs483353013  rs2229278  rs34577247  rs7397167  rs1565750061  rs569866427  rs17357542 
Subcellular location [CC][Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane;
Single-pass type I membrane protein. Membrane, coated pit.;
[Low-density lipoprotein receptor-related protein 1 515 kDa subunit]: Cell membrane;
Peripheral membrane protein;
Extracellular side. Membrane, coated pit.;
[Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm {ECO:0000269|PubMed:12888553}. Nucleus {ECO:0000269|PubMed:12888553}. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:12888553}.;
Golgi outpost {ECO:0000250|UniProtKB:G3V928}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:G3V928}. Note=Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. {ECO:0000250|UniProtKB:G3V928}.
Mouse PG classificationNA
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