| Gene Information | |
|---|---|
| Gene Name | SYTL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 934 |
| Protein Names | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000137501 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9HCH5 |
| Gene Card | SYTL2 |
| Uniprot ID | Q9HCH5 |
| Pfam | PF00168; PF02318 |
| In ASD | no |
| Allosteric Prediction | no (-0.515498589) |
| Ortholog in Animals | Alpaca_ SYTL2 ( ortholog_one2one ) Dog_ SYTL2 ( ortholog_one2one ) Macaque_ SYTL2 ( ortholog_one2one ) Mouse_ Sytl2 ( ortholog_one2one ) Pig_ SYTL2 ( ortholog_one2one ) Rat_ Sytl2 ( ortholog_one2one ) Rabbit_ SYTL2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SYT2, SYTL3, SYT13, TC2N, SYT1, SYT7, SYTL4, SYTL5, DOC2B, DOC2A, SYT14, C2CD4C, SYTL1, RPH3A, SYT8, SYT4, SYT11, SYT12, C2CD4A, C2CD4B, RPH3AL, SYT15, SYT15B, SYT9, SYT16, SYT6, C2CD4D, SYT3, SYT10, SYT5, SYT17 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3BC1 (X-ray 1.80A ) 7OPP (X-ray 2.32A ) 7OPQ (X-ray 2.23A ) 7OPR (X-ray 2.32A ) |
| DBSNP | rs556669 rs641393 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:18812475}. Cell membrane {ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A. {ECO:0000269|PubMed:18812475}.; [Isoform 4]: Cell membrane {ECO:0000269|PubMed:17182843}. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. {ECO:0000269|PubMed:17182843}. |
| Mouse PG classification | NA |
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