| Gene Information | |
|---|---|
| Gene Name | UBN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1134 |
| Protein Names | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000118900 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NPG3 |
| Gene Card | UBN1 |
| Uniprot ID | Q9NPG3 |
| Pfam | PF08729; PF14075 |
| In ASD | no |
| Allosteric Prediction | no (-0.128632395) |
| Ortholog in Animals | Alpaca_ UBN1 ( ortholog_one2one ) Dog_ UBN1 ( ortholog_one2one ) GuineaPig_ UBN1 ( ortholog_one2one ) Macaque_ UBN1 ( ortholog_one2one ) Mouse_ Ubn1 ( ortholog_one2one ) Pig_ UBN1 ( ortholog_one2one ) Rat_ Ubn1 ( ortholog_one2one ) Rabbit_ UBN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UBN2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Also expressed in numerous tumors and cancer cell lines. {ECO:0000269|PubMed:10725330, ECO:0000269|PubMed:19029251}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.100650(Mouse);0.003847(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4ZBJ (X-ray 2.25A ) |
| DBSNP | rs35103368 |
| Subcellular location [CC] | Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis. |
| Mouse PG classification | NA |
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