| Gene Information | |
|---|---|
| Gene Name | LRAT |
| Organism | Homo sapiens (Human) |
| Gene Length | 230 |
| Protein Names | Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase) |
| Target Name | lecithin retinol acyltransferase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000121207 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O95237 |
| Gene Card | LRAT |
| Uniprot ID | O95237 |
| Pfam | PF04970 |
| In ASD | no |
| Allosteric Prediction | no (-0.451153043) |
| Ortholog in Animals | Alpaca_ LRAT ( ortholog_one2one ) Dog_ LRAT ( ortholog_one2one ) GuineaPig_ LRAT ( ortholog_one2one ) Macaque_ LRAT ( ortholog_one2one ) Mouse_ Lrat ( ortholog_one2one ) Pig_ LRAT ( ortholog_one2one ) Rat_ Lrat ( ortholog_one2one ) Rabbit_ LRAT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LRATD1, PLAAT4, LRATD2, PLAAT5, PLAAT1, PLAAT2, PLAAT3 |
| Tissue | NA |
| Tissue Specificity | Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain. {ECO:0000269|PubMed:18544127, ECO:0000269|PubMed:9920938}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1448665709 rs104893848 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Rough endoplasmic reticulum {ECO:0000250}. Endosome, multivesicular body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity). {ECO:0000250}. |
| Mouse PG classification | HPG |
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