| Gene Information | |
|---|---|
| Gene Name | LPXN |
| Organism | Homo sapiens (Human) |
| Gene Length | 386 |
| Protein Names | Leupaxin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000110031 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60711 |
| Gene Card | LPXN |
| Uniprot ID | O60711 |
| Pfam | PF00412 |
| In ASD | no |
| Allosteric Prediction | no (-0.609733432) |
| Ortholog in Animals | Alpaca_ LPXN ( ortholog_one2one ) GuineaPig_ LPXN ( ortholog_one2one ) Macaque_ LPXN ( ortholog_one2one ) Mouse_ Lpxn ( ortholog_one2one ) Pig_ LPXN ( ortholog_one2one ) Rat_ Lpxn ( ortholog_one2one ) Rabbit_ LPXN ( ortholog_one2one ) |
| Ohnologs | TGFB1I1 |
| Paralogs | TGFB1I1, PXN |
| Tissue | NA |
| Tissue Specificity | Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression. {ECO:0000269|PubMed:12674328, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1X3H (NMR - ) 4XEF (X-ray 2.50A ) 4XEK (X-ray 1.79A ) 4XEV (X-ray 2.01A ) |
| DBSNP | rs12271558 |
| Subcellular location [CC] | Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin. |
| Mouse PG classification | NA |
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