Gene Information
Gene NameLPL
OrganismHomo sapiens (Human)
Gene Length475
Protein NamesLipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32)
Target Namelipoprotein lipase
Target TypeNA
Gene Age645 ( ENSG00000175445 )
Evolutionary StageEumetazoa
AlphaFoldDBP06858
Gene CardLPL
Uniprot IDP06858
PfamPF00151; PF01477
In ASDyes
Allosteric Predictionyes (1.000040034)
Ortholog in AnimalsAlpaca_ LPL ( ortholog_one2one )
Dog_ LPL ( ortholog_one2one )
GuineaPig_ LPL ( ortholog_one2one )
Macaque_ LPL ( ortholog_one2one )
Mouse_ Lpl ( ortholog_one2one )
Pig_ LPL ( ortholog_one2one )
Rat_ Lpl ( ortholog_one2one )
Rabbit_ LPL ( ortholog_one2one )
OhnologsLIPG, LIPC
ParalogsPNLIP, PLA1A, PNLIPRP3, LIPI, LIPC, PNLIPRP2, LIPH, PNLIPRP1, LIPG
TissueNA
Tissue SpecificityDetected in blood plasma (PubMed:2340307, PubMed:11893776, PubMed:12641539). Detected in milk (at protein level) (PubMed:2340307). {ECO:0000269|PubMed:11893776, ECO:0000269|PubMed:12641539, ECO:0000269|PubMed:2340307}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6E7K  (X-ray  2.80A  )  6OAU  (X-ray  2.48A  )  6OAZ  (X-ray  3.04A  )  6OB0  (X-ray  2.81A  )  6WN4  (X-ray  2.80A  ) 
DBSNP rs1801177  rs11542065  rs373088068  rs145657341  rs118204073  rs118204069  rs118204063  rs118204064  rs781614031  rs781614031  rs748349562  rs118204072  rs118204056  rs118204076  rs568397156  rs118204057  rs757546424  rs118204061  rs118204075  rs528243561  rs118204067  rs770601263  rs118204060  rs118204080  rs118204082  rs118204077  rs118204062  rs118204059  rs118204068  rs35414700  rs371282890  rs1800011  rs1161884343  rs773235712  rs1409123950  rs268  rs761265900  rs1181582051  rs118204071  rs546542623  rs298  rs300  rs118204078  rs5934  rs118204079  rs149089920 
Subcellular location [CC]Cell membrane {ECO:0000250|UniProtKB:P11151};
Peripheral membrane protein {ECO:0000250|UniProtKB:P11151};
Extracellular side {ECO:0000250|UniProtKB:P11151}. Secreted {ECO:0000269|PubMed:11342582, ECO:0000269|PubMed:11893776, ECO:0000269|PubMed:12641539, ECO:0000269|PubMed:1371284, ECO:0000269|PubMed:2340307, ECO:0000269|PubMed:27578112, ECO:0000269|PubMed:30559189}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:27811232}. Note=Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells (PubMed:27811232). Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). {ECO:0000250|UniProtKB:P11151, ECO:0000269|PubMed:27811232}.
Mouse PG classificationHPG
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