| Gene Information | |
|---|---|
| Gene Name | LPIN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 890 |
| Protein Names | Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000134324 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14693 |
| Gene Card | LPIN1 |
| Uniprot ID | Q14693 |
| Pfam | PF16876; PF04571; PF08235 |
| In ASD | no |
| Allosteric Prediction | yes (0.122575926) |
| Ortholog in Animals | Alpaca_ LPIN1 ( ortholog_one2one ) Dog_ LPIN1 ( ortholog_one2one ) GuineaPig_ LPIN1 ( ortholog_one2one ) Macaque_ LPIN1 ( ortholog_one2one ) Mouse_ Lpin1 ( ortholog_one2one ) Pig_ LPIN1 ( ortholog_one2one ) Rat_ Lpin1 ( ortholog_one2one ) Rabbit_ LPIN1 ( ortholog_one2one ) |
| Ohnologs | LPIN2, LPIN3 |
| Paralogs | AP5Z1, LPIN2, LPIN3 |
| Tissue | testis |
| Tissue Specificity | Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. {ECO:0000269|PubMed:17158099, ECO:0000269|PubMed:22134922}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4669781 rs17852755 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:29765047}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:29765047}. Nucleus membrane {ECO:0000250|UniProtKB:Q91ZP3}. Note=Translocates from the cytosol to the endoplasmic reticulum following acetylation by KAT5. {ECO:0000269|PubMed:29765047}. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |