| Gene Information | |
|---|---|
| Gene Name | ACAD8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 415 |
| Protein Names | Isobutyryl-CoA dehydrogenase, mitochondrial (IBDH) (EC 1.3.8.-) (Activator-recruited cofactor 42 kDa component) (ARC42) (Acyl-CoA dehydrogenase family member 8) (ACAD-8) |
| Target Name | isobutyryl-coa dehydrogenase, mitochondrial |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000151498 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UKU7 |
| Gene Card | ACAD8 |
| Uniprot ID | Q9UKU7 |
| Pfam | PF00441; PF02770; PF02771 |
| In ASD | no |
| Allosteric Prediction | no (-0.349604039) |
| Ortholog in Animals | Alpaca_ ACAD8 ( ortholog_one2one ) Dog_ ACAD8 ( ortholog_one2one ) GuineaPig_ ACAD8 ( ortholog_one2one ) Macaque_ ACAD8 ( ortholog_one2one ) Mouse_ Acad8 ( ortholog_one2one ) Pig_ ACAD8 ( ortholog_one2one ) Rat_ Acad8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ACOX1, ACAD11, ACADM, ACAD9, IVD, GCDH, ACOXL, ACAD10, ACADS, ACOX3, ACOX2, ACADVL, ACADSB, ACADL |
| Tissue | NA |
| Tissue Specificity | Detected at comparable levels in all tissues examined (heart, lung, brain, skeletal muscle, pancreas and placenta). Weakly expressed in liver and kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1RX0 (X-ray 1.77A ) |
| DBSNP | rs374317179 rs367857040 rs371449613 rs121908418 rs759877257 rs121908422 rs200620279 rs778823613 rs367996531 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:11013134, ECO:0000269|PubMed:12359132}. |
| Mouse PG classification | LPG |
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