| Gene Information | |
|---|---|
| Gene Name | LPAR6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 344 |
| Protein Names | Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5) (RB intron encoded G-protein coupled receptor) |
| Target Name | lysophosphatidic acid receptor 6 |
| Target Type | Literature-reported target |
| Gene Age | 454 ( ENSG00000139679 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P43657 |
| Gene Card | LPAR6 |
| Uniprot ID | P43657 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.458433424) |
| Ortholog in Animals | Alpaca_ LPAR6 ( ortholog_one2one ) GuineaPig_ LPAR6 ( ortholog_one2one ) Mouse_ Lpar6 ( ortholog_one2one ) Pig_ LPAR6 ( ortholog_one2one ) Rat_ Lpar6 ( ortholog_one2one ) Rabbit_ LPAR6 ( ortholog_one2one ) |
| Ohnologs | LPAR4 |
| Paralogs | F2RL2, P2RY8, F2RL1, F2R, F2RL3, GPR18, GPR65, CYSLTR2, GPR17, GPR4, CYSLTR1, GPR20, LPAR4, P2RY10, GPR35, GPR55 |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes. {ECO:0000269|PubMed:11004484, ECO:0000269|PubMed:18297070, ECO:0000269|PubMed:18297072}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1060585 rs879255262 rs4151553 rs121434307 rs121434309 rs17071686 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18297070}; Multi-pass membrane protein {ECO:0000269|PubMed:18297070}. |
| Mouse PG classification | NA |
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