| Gene Information | |
|---|---|
| Gene Name | HIP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1037 |
| Protein Names | Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000127946 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00291 |
| Gene Card | HIP1 |
| Uniprot ID | O00291 |
| Pfam | PF07651; PF16515; PF01608 |
| In ASD | no |
| Allosteric Prediction | yes (0.294468634) |
| Ortholog in Animals | Alpaca_ HIP1 ( ortholog_one2many ) Dog_ HIP1 ( ortholog_one2one ) GuineaPig_ HIP1 ( ortholog_one2one ) Macaque_ HIP1 ( ortholog_one2one ) Mouse_ Hip1 ( ortholog_one2one ) Pig_ HIP1 ( ortholog_one2one ) Rat_ Hip1 ( ortholog_one2one ) Rabbit_ HIP1 ( ortholog_one2one ) |
| Ohnologs | HIP1R |
| Paralogs | HIP1R |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer. {ECO:0000269|PubMed:12163454, ECO:0000269|PubMed:9140394, ECO:0000269|PubMed:9147654}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2NO2 (X-ray 2.80A ) 2QA7 (X-ray 2.80A ) 3I00 (X-ray 2.30A ) |
| DBSNP | rs17149023 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR. |
| Mouse PG classification | NA |
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