| Gene Information | |
|---|---|
| Gene Name | LPAR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 353 |
| Protein Names | Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7) |
| Target Name | lysophosphatidate-3 receptor |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000171517 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UBY5 |
| Gene Card | LPAR3 |
| Uniprot ID | Q9UBY5 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.972228315) |
| Ortholog in Animals | Alpaca_ LPAR3 ( ortholog_one2one ) Dog_ LPAR3 ( ortholog_one2one ) GuineaPig_ LPAR3 ( ortholog_one2one ) Macaque_ LPAR3 ( ortholog_one2one ) Mouse_ Lpar3 ( ortholog_one2one ) Pig_ LPAR3 ( ortholog_one2one ) Rat_ Lpar3 ( ortholog_one2one ) Rabbit_ LPAR3 ( ortholog_one2one ) |
| Ohnologs | LPAR2, S1PR4, S1PR5, GPR3, LPAR1, S1PR3 |
| Paralogs | GPR3, GPR119, GPR6, GPR12, CNR1, CNR2, MC5R, MC1R, MC2R, MC3R, MC4R, S1PR1, S1PR5, S1PR2, S1PR3, S1PR4, LPAR2, LPAR1 |
| Tissue | oviduct, testis |
| Tissue Specificity | Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs35745543 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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