| Gene Information | |
|---|---|
| Gene Name | LPAR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 348 |
| Protein Names | Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000064547 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9HBW0 |
| Gene Card | LPAR2 |
| Uniprot ID | Q9HBW0 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.984189909) |
| Ortholog in Animals | Alpaca_ LPAR2 ( ortholog_one2one ) Dog_ LPAR2 ( ortholog_one2one ) GuineaPig_ LPAR2 ( ortholog_one2one ) Macaque_ LPAR2 ( ortholog_one2one ) Mouse_ Lpar2 ( ortholog_one2one ) Pig_ LPAR2 ( ortholog_one2one ) Rat_ Lpar2 ( ortholog_one2one ) Rabbit_ LPAR2 ( ortholog_one2one ) |
| Ohnologs | MC3R, S1PR4, S1PR5, S1PR1, LPAR3, GPR3, LPAR1, S1PR3 |
| Paralogs | GPR3, GPR119, GPR6, GPR12, CNR1, CNR2, MC5R, MC1R, MC2R, MC3R, MC4R, S1PR1, S1PR5, S1PR2, S1PR3, S1PR4, LPAR3, LPAR1 |
| Tissue | NA |
| Tissue Specificity | Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4P0C (X-ray 1.34A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell surface {ECO:0000269|PubMed:19306925}. Cell membrane {ECO:0000269|PubMed:19306925}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles. |
| Mouse PG classification | NA |
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