| Gene Information | |
|---|---|
| Gene Name | LOX |
| Organism | Homo sapiens (Human) |
| Gene Length | 417 |
| Protein Names | Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000113083 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P28300 |
| Gene Card | LOX |
| Uniprot ID | P28300 |
| Pfam | PF01186 |
| In ASD | no |
| Allosteric Prediction | no (-0.063125233) |
| Ortholog in Animals | Alpaca_ LOX ( ortholog_one2one ) Dog_ LOX ( ortholog_one2one ) Macaque_ LOX ( ortholog_one2one ) Mouse_ Lox ( ortholog_one2one ) Pig_ LOX ( ortholog_one2one ) Rat_ Lox ( ortholog_one2one ) Rabbit_ LOX ( ortholog_one2one ) |
| Ohnologs | LOXL1 |
| Paralogs | CD6, SSC4D, SSC5D, LGALS3BP, LOXL4, SCART1, CD163, PRSS12, DMBT1, LOXL3, CD5, LOXL1, CD5L, LOXL2, CD163L1 |
| Tissue | bone.marrow, dura.mater, tricuspid.valve, zone.of.skin |
| Tissue Specificity | Heart, placenta, skeletal muscle, kidney, lung and pancreas. {ECO:0000269|PubMed:7706256}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs752839330 rs767855588 rs1800449 rs1561420103 rs886040967 rs886040965 rs876657852 rs1561417568 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:31152061}. Secreted, extracellular space. |
| Mouse PG classification | NA |
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