| Gene Information | |
|---|---|
| Gene Name | PGRMC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 223 |
| Protein Names | Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000164040 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15173 |
| Gene Card | PGRMC2 |
| Uniprot ID | O15173 |
| Pfam | PF00173 |
| In ASD | no |
| Allosteric Prediction | no (-0.809222118) |
| Ortholog in Animals | Alpaca_ PGRMC2 ( ortholog_one2one ) Dog_ PGRMC2 ( ortholog_one2one ) GuineaPig_ PGRMC2 ( ortholog_one2one ) Macaque_ PGRMC2 ( ortholog_one2one ) Mouse_ Pgrmc2 ( ortholog_one2one ) Pig_ PGRMC2 ( ortholog_one2one ) Rat_ Pgrmc2 ( ortholog_one2one ) |
| Ohnologs | PGRMC1, NENF |
| Paralogs | CYB5D2, PGRMC1, VMP1 |
| Tissue | NA |
| Tissue Specificity | Expressed by endometrial glands and stroma (at protein level). {ECO:0000269|PubMed:23793472}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000305|PubMed:23793472}; Single-pass membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:27754849, ECO:0000269|PubMed:28111073}. Endoplasmic reticulum {ECO:0000269|PubMed:27754849}. |
| Mouse PG classification | NA |
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