| Gene Information | |
|---|---|
| Gene Name | LNX3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1066 |
| Protein Names | E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UPQ7 |
| Gene Card | PDZRN3 |
| Uniprot ID | Q9UPQ7 |
| Pfam | PF00595 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors. {ECO:0000269|PubMed:10470851, ECO:0000269|PubMed:15305371, ECO:0000269|PubMed:17118964}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1UHP (NMR - ) 1WH1 (NMR - ) |
| DBSNP | rs3205537 |
| Subcellular location [CC] | Synapse {ECO:0000250|UniProtKB:Q69ZS0}. Cytoplasm {ECO:0000250|UniProtKB:E7FDW2}. Note=Localizes to the postsynaptic region of neuromuscular junctions. {ECO:0000250|UniProtKB:Q69ZS0}. |
| Mouse PG classification | NA |
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