Gene Information
Gene NameLNPK
OrganismHomo sapiens (Human)
Gene Length428
Protein NamesEndoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000144320 )
Evolutionary StageEukaryota
AlphaFoldDBQ9C0E8
Gene CardLNPK
Uniprot IDQ9C0E8
PfamPF10058
In ASDno
Allosteric Predictionno (-1.740412999)
Ortholog in AnimalsAlpaca_ LNPK ( ortholog_one2one )
Dog_ LNPK ( ortholog_one2one )
GuineaPig_ LNPK ( ortholog_one2one )
Macaque_ LNPK ( ortholog_one2one )
Mouse_ Lnpk ( ortholog_one2one )
Pig_ LNPK ( ortholog_one2one )
Rat_ Lnpk ( ortholog_one2one )
Rabbit_ LNPK ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in neural precursor cells, where it is detected at the growth-cone-like structure and branching sites of neurite-like processes. {ECO:0000269|PubMed:30032983}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:22729086, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977};
Multi-pass membrane protein {ECO:0000269|PubMed:22729086, ECO:0000269|PubMed:24223779};
Cytoplasmic side {ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25548161}. Note=Localizes at endoplasmic reticulum (ER) three-way tubular junctions, which represent crossing-points at which the tubules build a polygonal network (PubMed:22729086, PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). {ECO:0000269|PubMed:22729086, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977}.
Mouse PG classificationNA
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