| Gene Information | |
|---|---|
| Gene Name | LNPEP |
| Organism | Homo sapiens (Human) |
| Gene Length | 1025 |
| Protein Names | Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000113441 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9UIQ6 |
| Gene Card | LNPEP |
| Uniprot ID | Q9UIQ6 |
| Pfam | PF11838; PF01433; PF17900 |
| In ASD | yes |
| Allosteric Prediction | yes (0.317108016) |
| Ortholog in Animals | Alpaca_ LNPEP ( ortholog_one2one ) Dog_ LNPEP ( ortholog_one2one ) GuineaPig_ LNPEP ( ortholog_one2one ) Macaque_ LNPEP ( ortholog_one2one ) Mouse_ Lnpep ( ortholog_one2one ) Pig_ LNPEP ( ortholog_one2one ) Rat_ Lnpep ( ortholog_one2one ) Rabbit_ LNPEP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNPEPL1, NPEPPS, ERAP1, ENPEP, AOPEP, LTA4H, TRHDE, LVRN, ANPEP, RNPEP, ERAP2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:8550619, ECO:0000269|PubMed:9177475}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4P8Q (X-ray 3.02A ) 4PJ6 (X-ray 2.96A ) 4Z7I (X-ray 3.31A ) 5C97 (X-ray 3.37A ) 5JHQ (X-ray 3.20A ) 5MJ6 (X-ray 2.53A ) 7ZYF (X-ray 2.81A ) |
| DBSNP | rs3797799 rs12520455 rs2303138 rs17087233 rs11746232 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269|PubMed:11389728}. Note=In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.; [Leucyl-cystinyl aminopeptidase, pregnancy serum form]: Secreted. Note=During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition. |
| Mouse PG classification | NA |
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