| Gene Information | |
|---|---|
| Gene Name | LMNB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 586 |
| Protein Names | Lamin-B1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000113368 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P20700 |
| Gene Card | LMNB1 |
| Uniprot ID | P20700 |
| Pfam | PF00038; PF00932 |
| In ASD | no |
| Allosteric Prediction | yes (0.444200943) |
| Ortholog in Animals | Alpaca_ LMNB1 ( ortholog_one2one ) Alpaca_ LMNB1 ( ortholog_one2many ) Dog_ LMNB1 ( ortholog_one2one ) GuineaPig_ LMNB1 ( ortholog_one2one ) Macaque_ LMNB1 ( ortholog_one2one ) Mouse_ Lmnb1 ( ortholog_one2one ) Pig_ LMNB1 ( ortholog_one2one ) Rat_ Lmnb1 ( ortholog_one2one ) Rabbit_ LMNB1 ( ortholog_one2one ) |
| Ohnologs | LMNB2, LMNA |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.019824(Chimpanzee);0.001000(Mouse);0.001704(Rat);0.025000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2KPW (NMR - ) 3JT0 (X-ray 2.39A ) 3TYY (X-ray 2.40A ) 3UMN (X-ray 2.00A ) 5VVX (X-ray 2.90A ) 7DTG (X-ray 3.60A ) |
| DBSNP | rs1295707923 rs1750497172 rs1303994586 rs1750506249 rs1380634377 rs36105360 |
| Subcellular location [CC] | Nucleus lamina {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| Mouse PG classification | LPG |
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