| Gene Information | |
|---|---|
| Gene Name | LMAN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 510 |
| Protein Names | Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1) |
| Target Name | protein ergic-53 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000074695 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49257 |
| Gene Card | LMAN1 |
| Uniprot ID | P49257 |
| Pfam | PF03388 |
| In ASD | no |
| Allosteric Prediction | no (-0.248825072) |
| Ortholog in Animals | Alpaca_ LMAN1 ( ortholog_one2one ) Dog_ LMAN1 ( ortholog_one2one ) GuineaPig_ LMAN1 ( ortholog_one2one ) Macaque_ LMAN1 ( ortholog_one2one ) Mouse_ Lman1 ( ortholog_one2one ) Pig_ LMAN1 ( ortholog_one2one ) Rat_ Lman1 ( ortholog_one2one ) Rabbit_ LMAN1 ( ortholog_one2one ) |
| Ohnologs | LMAN1L |
| Paralogs | LMAN2L, LMAN1L, LMAN2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:13130098}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.047368(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3A4U (X-ray 1.84A ) 3LCP (X-ray 2.45A ) 3WHT (X-ray 1.80A ) 3WHU (X-ray 2.60A ) 3WNX (X-ray 2.75A ) 4GKX (X-ray 2.70A ) 4GKY (X-ray 2.42A ) 4YGB (X-ray 1.60A ) 4YGC (X-ray 2.40A ) 4YGD (X-ray 2.51A ) 4YGE (X-ray 3.05A ) |
| DBSNP | rs1043302 rs33926449 rs3737392 rs2298711 |
| Subcellular location [CC] | Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Mouse PG classification | LPG |
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