| Gene Information | |
|---|---|
| Gene Name | LLGL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1020 |
| Protein Names | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000073350 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q6P1M3 |
| Gene Card | LLGL2 |
| Uniprot ID | Q6P1M3 |
| Pfam | PF08366; PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.436359307) |
| Ortholog in Animals | Alpaca_ LLGL2 ( ortholog_one2one ) Dog_ LLGL2 ( ortholog_one2one ) GuineaPig_ LLGL2 ( ortholog_one2one ) Macaque_ LLGL2 ( ortholog_one2one ) Mouse_ Llgl2 ( ortholog_one2one ) Pig_ LLGL2 ( ortholog_one2one ) Rat_ Llgl2 ( ortholog_one2one ) Rabbit_ LLGL2 ( ortholog_one2one ) |
| Ohnologs | LLGL1 |
| Paralogs | LLGL1, STXBP5, STXBP5L |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.155636(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3WP0 (X-ray 2.04A ) 3WP1 (X-ray 2.80A ) 6N8P (X-ray 3.19A ) 6N8Q (X-ray 2.20A ) 6N8R (X-ray 1.91A ) 6N8S (X-ray 3.90A ) |
| DBSNP | rs1671036 rs1671021 rs35991442 rs1671021 rs35474687 rs1661715 rs1661714 rs35886912 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15632202}. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells. |
| Mouse PG classification | NA |
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