Gene Information
Gene NameLITAF
OrganismHomo sapiens (Human)
Gene Length161
Protein NamesLipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000189067 )
Evolutionary StageEukaryota
AlphaFoldDBQ99732
Gene CardLITAF
Uniprot IDQ99732
PfamPF10601
In ASDno
Allosteric Predictionno (-0.962193506)
Ortholog in AnimalsAlpaca_ LITAF ( ortholog_one2one )
Dog_ LITAF ( ortholog_one2one )
GuineaPig_ LITAF ( ortholog_one2one )
Mouse_ Litaf ( ortholog_one2one )
Rat_ Litaf ( ortholog_one2many )
Rabbit_ LITAF ( ortholog_one2one )
OhnologsNA
ParalogsCDIP1
TissueNA
Tissue SpecificityUbiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. {ECO:0000269|PubMed:10200294, ECO:0000269|PubMed:11274176}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs141862602  rs4280262  rs104894519  rs104894520  rs104894521  rs104894522 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:15793005}. Nucleus {ECO:0000269|PubMed:15793005, ECO:0000269|PubMed:16954198}. Lysosome membrane {ECO:0000269|PubMed:11274176, ECO:0000269|PubMed:27582497};
Peripheral membrane protein {ECO:0000269|PubMed:11274176};
Cytoplasmic side {ECO:0000269|PubMed:11274176}. Early endosome membrane {ECO:0000269|PubMed:21896645, ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:27582497}. Late endosome membrane {ECO:0000269|PubMed:27582497}. Endosome membrane {ECO:0000269|PubMed:27927196};
Peripheral membrane protein {ECO:0000269|PubMed:27927196};
Cytoplasmic side {ECO:0000269|PubMed:27927196}. Cell membrane {ECO:0000269|PubMed:16118794, ECO:0000269|PubMed:27582497};
Peripheral membrane protein {ECO:0000269|PubMed:27582497};
Cytoplasmic side {ECO:0000269|PubMed:27582497}. Golgi apparatus membrane {ECO:0000269|PubMed:16118794}. Note=Associated with membranes of lysosomes, early and late endosomes (PubMed:11274176, PubMed:27927196, PubMed:27582497). Can translocate from the cytoplasm into the nucleus (PubMed:15793005). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity). {ECO:0000250|UniProtKB:Q9JLJ0, ECO:0000269|PubMed:11274176, ECO:0000269|PubMed:15793005, ECO:0000269|PubMed:27582497, ECO:0000269|PubMed:27927196}.
Mouse PG classificationNA
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