| Gene Information | |
|---|---|
| Gene Name | LIR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 650 |
| Protein Names | Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8NHL6 |
| Gene Card | LILRB1 |
| Uniprot ID | Q8NHL6 |
| Pfam | PF00047; PF13895 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in B cells, monocytes and various dendritic cell (DC) subsets including myeloid, plasmacytoid and tolerogenic DCs (at protein level) (PubMed:20448110, PubMed:9285411, PubMed:9842885, PubMed:24453251). Expressed in decidual macrophages (at protein level) (PubMed:19304799). Expressed in decidual NK cells (at protein level) (PubMed:29262349). {ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:29262349, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1G0X (X-ray 2.10A ) 1P7Q (X-ray 3.40A ) 1UFU (X-ray 3.00A ) 1UGN (X-ray 1.80A ) 1VDG (X-ray 2.80A ) 3D2U (X-ray 2.21A ) 4LL9 (X-ray 2.69A ) 4NO0 (X-ray 2.70A ) 5KNM (X-ray 3.30A ) 6AEE (X-ray 3.30A ) 6EWA (X-ray 2.39A ) 6EWC (X-ray 3.20A ) 6EWO (X-ray 2.30A ) 6K60 (X-ray 3.15A ) 6ZDX (X-ray 3.00A ) 7KFK (X-ray 2.63A ) |
| DBSNP | rs1061679 rs12460501 rs1061680 rs1061681 rs1045818 rs1138737 rs634222 rs16985478 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:29262349, ECO:0000305|PubMed:19658091}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 5]: Secreted {ECO:0000269|PubMed:19658091}. |
| Mouse PG classification | NA |
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