| Gene Information | |
|---|---|
| Gene Name | LIPG |
| Organism | Homo sapiens (Human) |
| Gene Length | 500 |
| Protein Names | Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) (Phospholipase A1) (EC 3.1.1.32) |
| Target Name | endothelial lipase |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000101670 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y5X9 |
| Gene Card | LIPG |
| Uniprot ID | Q9Y5X9 |
| Pfam | PF00151; PF01477 |
| In ASD | no |
| Allosteric Prediction | no (-0.563097141) |
| Ortholog in Animals | Alpaca_ LIPG ( ortholog_one2one ) Dog_ LIPG ( ortholog_one2one ) GuineaPig_ LIPG ( ortholog_one2one ) Macaque_ LIPG ( ortholog_one2one ) Mouse_ Lipg ( ortholog_one2one ) Pig_ LIPG ( ortholog_one2one ) Rat_ Lipg ( ortholog_one2one ) Rabbit_ LIPG ( ortholog_one2one ) |
| Ohnologs | LIPC, LPL |
| Paralogs | PNLIP, PLA1A, PNLIPRP3, LIPI, LIPC, PNLIPRP2, LIPH, PNLIPRP1, LPL |
| Tissue | placenta, thyroid |
| Tissue Specificity | High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle. {ECO:0000269|PubMed:10192396, ECO:0000269|PubMed:10318835}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9963243 rs150879681 rs2000813 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:10318835}. |
| Mouse PG classification | NA |
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