| Gene Information | |
|---|---|
| Gene Name | LIPD |
| Organism | Homo sapiens (Human) |
| Gene Length | 475 |
| Protein Names | Lipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P06858 |
| Gene Card | LPL |
| Uniprot ID | P06858 |
| Pfam | PF00151; PF01477 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in blood plasma (PubMed:2340307, PubMed:11893776, PubMed:12641539). Detected in milk (at protein level) (PubMed:2340307). {ECO:0000269|PubMed:11893776, ECO:0000269|PubMed:12641539, ECO:0000269|PubMed:2340307}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6E7K (X-ray 2.80A ) 6OAU (X-ray 2.48A ) 6OAZ (X-ray 3.04A ) 6OB0 (X-ray 2.81A ) 6WN4 (X-ray 2.80A ) |
| DBSNP | rs1801177 rs11542065 rs373088068 rs145657341 rs118204073 rs118204069 rs118204063 rs118204064 rs781614031 rs781614031 rs748349562 rs118204072 rs118204056 rs118204076 rs568397156 rs118204057 rs757546424 rs118204061 rs118204075 rs528243561 rs118204067 rs770601263 rs118204060 rs118204080 rs118204082 rs118204077 rs118204062 rs118204059 rs118204068 rs35414700 rs371282890 rs1800011 rs1161884343 rs773235712 rs1409123950 rs268 rs761265900 rs1181582051 rs118204071 rs546542623 rs298 rs300 rs118204078 rs5934 rs118204079 rs149089920 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P11151}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11151}; Extracellular side {ECO:0000250|UniProtKB:P11151}. Secreted {ECO:0000269|PubMed:11342582, ECO:0000269|PubMed:11893776, ECO:0000269|PubMed:12641539, ECO:0000269|PubMed:1371284, ECO:0000269|PubMed:2340307, ECO:0000269|PubMed:27578112, ECO:0000269|PubMed:30559189}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:27811232}. Note=Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells (PubMed:27811232). Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). {ECO:0000250|UniProtKB:P11151, ECO:0000269|PubMed:27811232}. |
| Mouse PG classification | NA |
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