| Gene Information | |
|---|---|
| Gene Name | ATF6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 670 |
| Protein Names | Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] |
| Target Name | activator protein 1 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000118217 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P18850 |
| Gene Card | ATF6 |
| Uniprot ID | P18850 |
| Pfam | PF00170 |
| In ASD | no |
| Allosteric Prediction | yes (0.16899378) |
| Ortholog in Animals | Alpaca_ ATF6 ( ortholog_one2one ) Dog_ ATF6 ( ortholog_one2one ) GuineaPig_ ATF6 ( ortholog_one2one ) Macaque_ ATF6 ( ortholog_one2one ) Mouse_ Atf6 ( ortholog_one2one ) Pig_ ATF6 ( ortholog_one2one ) Rat_ Atf6 ( ortholog_one2one ) Rabbit_ ATF6 ( ortholog_one2one ) |
| Ohnologs | ATF6B |
| Paralogs | CREB3L2, CREB3L3, ATF1, ATF6B, CREB3L4, CREB1, CREB3L1, CREM, CREB3 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:9271374}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1058405 rs1058405 rs2070150 rs1135983 rs761357250 rs796065053 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12782636}; Single-pass type II membrane protein {ECO:0000255}. Note=Translocates from the endoplasmic reticulum to the Golgi, where it is processed. {ECO:0000269|PubMed:12782636}.; [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (PubMed:10564271, PubMed:12782636). THBS4 promotes its nuclear shuttling (By similarity). {ECO:0000250|UniProtKB:F6VAN0, ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}. |
| Mouse PG classification | LPG |
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