| Gene Information | |
|---|---|
| Gene Name | LIP |
| Organism | Homo sapiens (Human) |
| Gene Length | 3661 |
| Protein Names | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | NA |
| Gene Card | SMG1 |
| Uniprot ID | Q96Q15 |
| Pfam | PF02260; PF00454; PF15785; PF17229 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest level in heart and skeletal muscle. Expressed in placenta, brain, lung and spleen, but not in liver. {ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:8524286}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.086667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6L53 (EM 3.63A ) 6L54 (EM 3.43A ) 6SYT (EM 3.45A ) 6Z3R (EM 2.97A ) 7PW4 (EM 3.27A ) 7PW5 (EM 3.40A ) 7PW6 (EM 3.05A ) 7PW7 (EM 3.59A ) 7PW8 (EM 2.82A ) 7PW9 (EM 3.12A ) |
| DBSNP | rs12051350 rs752796432 rs766737607 rs750788715 rs1382468496 rs200419100 rs376234691 rs750840136 rs17842615 rs569679854 rs919788709 rs1233400465 rs80176913 rs555078480 rs1412788971 rs1394431566 rs45516593 rs563883658 rs375411122 rs949474935 rs17731779 rs35572280 rs56276814 rs34960798 rs35952340 rs55782217 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15175154}. Cytoplasm {ECO:0000269|PubMed:15175154}. Note=Present in the chromatoid body. {ECO:0000250|UniProtKB:Q8BKX6}. |
| Mouse PG classification | NA |
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