Gene Information
Gene NameLINGO1
OrganismHomo sapiens (Human)
Gene Length620
Protein NamesLeucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)
Target Nameleucine-rich repeat neuronal protein 1
Target TypeClinical trial target
Gene Age645 ( ENSG00000169783 )
Evolutionary StageVertebrata
AlphaFoldDBQ96FE5
Gene CardLINGO1
Uniprot IDQ96FE5
PfamPF07679; PF13306; PF13855
In ASDno
Allosteric Predictionno (-0.67126358)
Ortholog in AnimalsAlpaca_ LINGO1 ( ortholog_one2one )
Dog_ LINGO1 ( ortholog_one2one )
GuineaPig_ LINGO1 ( ortholog_one2one )
Macaque_ LINGO1 ( ortholog_one2one )
Mouse_ Lingo1 ( ortholog_one2one )
Pig_ LINGO1 ( ortholog_one2one )
Rat_ Lingo1 ( ortholog_one2one )
Rabbit_ LINGO1 ( ortholog_one2one )
OhnologsLINGO3, LRRTM2, LINGO2, LINGO4
ParalogsTLR9, LRRC70, LRFN2, LRFN5, SLITRK3, LRFN4, GP5, SLITRK2, TPBGL, SLITRK6, LRFN1, LRRN1, SLITRK1, LRTM2, SLIT3, LRRN2, LRRN3, SLIT2, LRRC38, SLITRK4, LINGO2, SLIT1, SLITRK5, LRRC55, LRFN3
Tissuecerebral.cortex
Tissue SpecificityExpressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients. {ECO:0000269|PubMed:14686891, ECO:0000269|PubMed:15895088, ECO:0000269|PubMed:17726113}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2ID5  (X-ray  2.70A  )  4OQT  (X-ray  3.23A  ) 
DBSNP rs9855  rs750612085  rs757077698 
Subcellular location [CC]Cell membrane {ECO:0000250|UniProtKB:Q9D1T0};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D1T0}.
Mouse PG classificationNA
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