| Gene Information | |
|---|---|
| Gene Name | LIN28A |
| Organism | Homo sapiens (Human) |
| Gene Length | 209 |
| Protein Names | Protein lin-28 homolog A (Lin-28A) (Zinc finger CCHC domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000131914 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9H9Z2 |
| Gene Card | LIN28A |
| Uniprot ID | Q9H9Z2 |
| Pfam | PF00313; PF00098 |
| In ASD | no |
| Allosteric Prediction | no (-0.999630728) |
| Ortholog in Animals | Alpaca_ LIN28A ( ortholog_one2one ) Dog_ LIN28A ( ortholog_one2many ) Mouse_ Lin28a ( ortholog_one2one ) Pig_ LIN28A ( ortholog_one2one ) Rat_ Lin28a ( ortholog_one2one ) |
| Ohnologs | LIN28B |
| Paralogs | LIN28B, YBX2, YBX1, YBX3 |
| Tissue | NA |
| Tissue Specificity | Expressed in embryonic stem cells, placenta and testis. Tends to be up-regulated in HER2-overexpressing breast tumors. {ECO:0000269|PubMed:14688391, ECO:0000269|PubMed:15614775, ECO:0000269|PubMed:15722555, ECO:0000269|PubMed:22118463}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CQF (NMR - ) 2LI8 (NMR - ) 5UDZ (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:22118463}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q8K3Y3}. Cytoplasm, P-body {ECO:0000269|PubMed:17617744}. Cytoplasm, Stress granule {ECO:0000269|PubMed:17617744}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8K3Y3}. Note=Predominantly cytoplasmic (PubMed:22118463). In the cytoplasm, localizes to peri-endoplasmic reticulum regions and detected in the microsomal fraction derived from rough endoplasmic reticulum (RER) following subcellular fractionation. May be bound to the cytosolic surface of RER on which ER-associated mRNAs are translated (By similarity). Shuttle from the nucleus to the cytoplasm requires RNA-binding (PubMed:17617744). Nucleolar localization is observed in 10-15% of the nuclei in differentiated myotubes (By similarity). {ECO:0000250|UniProtKB:Q8K3Y3, ECO:0000269|PubMed:17617744, ECO:0000269|PubMed:22118463}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |