| Gene Information | |
|---|---|
| Gene Name | LIN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 926 |
| Protein Names | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O14936 |
| Gene Card | CASK |
| Uniprot ID | O14936 |
| Pfam | PF00625; PF02828; PF00595; PF00069; PF00018 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. {ECO:0000269|PubMed:11003712}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1KGD (X-ray 1.31A ) 1KWA (X-ray 1.93A ) 1ZL8 (NMR - ) 3C0G (X-ray 2.19A ) 3C0H (X-ray 2.30A ) 3C0I (X-ray 1.85A ) 3MFR (X-ray 2.00A ) 3MFS (X-ray 2.10A ) 3MFT (X-ray 2.20A ) 3MFU (X-ray 2.30A ) 3TAC (X-ray 2.20A ) 6KMH (X-ray 2.40A ) 7OAI (X-ray 2.30A ) 7OAJ (X-ray 1.93A ) 7OAK (X-ray 2.23A ) 7OAL (X-ray 2.17A ) |
| DBSNP | rs137852816 rs137852817 rs137852820 rs137852818 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q62915}. Cytoplasm {ECO:0000250|UniProtKB:Q62915}. Cell membrane {ECO:0000250|UniProtKB:Q62915}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62915}. |
| Mouse PG classification | NA |
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