| Gene Information | |
|---|---|
| Gene Name | LIMK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 638 |
| Protein Names | LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) |
| Target Name | lim domain kinase 2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000182541 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P53671 |
| Gene Card | LIMK2 |
| Uniprot ID | P53671 |
| Pfam | PF00412; PF00595; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (0.626228542) |
| Ortholog in Animals | Alpaca_ LIMK2 ( ortholog_one2one ) Dog_ LIMK2 ( ortholog_one2one ) GuineaPig_ LIMK2 ( ortholog_one2one ) Macaque_ LIMK2 ( ortholog_one2one ) Mouse_ Limk2 ( ortholog_one2one ) Pig_ LIMK2 ( ortholog_one2one ) Rat_ Limk2 ( ortholog_one2one ) Rabbit_ LIMK2 ( ortholog_one2one ) |
| Ohnologs | LIMK1 |
| Paralogs | RIPK1, LRRK2, TNNI3K, TESK2, KSR2, MAP3K10, RIPK2, MOS, MAP3K9, MLKL, MAP3K20, ARAF, TESK1, MAP3K13, BRAF, ILK, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, KSR1, RIPK3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1X6A (NMR - ) 4TPT (X-ray 2.60A ) 5NXD (X-ray 1.90A ) 7QHG (X-ray 1.45A ) |
| DBSNP | rs5997917 rs35923988 rs34930775 rs34875793 rs2229874 rs35422808 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22328514}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25849865}.; [Isoform LIMK2a]: Cytoplasm {ECO:0000269|PubMed:8954941}. Nucleus {ECO:0000269|PubMed:8954941}.; [Isoform LIMK2b]: Cytoplasm {ECO:0000269|PubMed:8954941}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8954941}. Nucleus {ECO:0000269|PubMed:8954941}. Note=Mainly present in the cytoplasm and is scarcely translocated to the nucleus. {ECO:0000269|PubMed:8954941}. |
| Mouse PG classification | NA |
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