| Gene Information | |
|---|---|
| Gene Name | LIMK |
| Organism | Homo sapiens (Human) |
| Gene Length | 647 |
| Protein Names | LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P53667 |
| Gene Card | LIMK1 |
| Uniprot ID | P53667 |
| Pfam | PF00412; PF00595; PF07714 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3S95 (X-ray 1.65A ) 5HVJ (X-ray 2.20A ) 5HVK (X-ray 3.50A ) 5L6W (X-ray 2.53A ) 5NXC (X-ray 2.25A ) 6WLY (X-ray 1.90A ) 7ATS (X-ray 2.80A ) 7ATU (X-ray 2.80A ) 7B8W (X-ray 2.80A ) 8AAU (X-ray 1.74A ) |
| DBSNP | rs35827364 rs55661242 rs55679316 rs178412 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21682918}. Nucleus {ECO:0000269|PubMed:21682918}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10196227, ECO:0000269|PubMed:16230460}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P53668}. Note=Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner. {ECO:0000250|UniProtKB:P53668}. |
| Mouse PG classification | NA |
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