| Gene Information | |
|---|---|
| Gene Name | GPR83 |
| Organism | Homo sapiens (Human) |
| Gene Length | 423 |
| Protein Names | G-protein coupled receptor 83 (G-protein coupled receptor 72) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000123901 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NYM4 |
| Gene Card | GPR83 |
| Uniprot ID | Q9NYM4 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.680012044) |
| Ortholog in Animals | Alpaca_ GPR83 ( ortholog_one2one ) Dog_ GPR83 ( ortholog_one2one ) GuineaPig_ GPR83 ( ortholog_one2one ) Mouse_ Gpr83 ( ortholog_one2one ) Pig_ GPR83 ( ortholog_one2one ) Rat_ Gpr83 ( ortholog_one2one ) Rabbit_ GPR83 ( ortholog_one2one ) |
| Ohnologs | BRS3, HCRTR2, NPY1R, NPY2R, NPY4R |
| Paralogs | TACR2, OR9A2, NPY1R, MTNR1B, OR11H6, OR11H7, OR11H4, OR9A1P, OR9G1, NPY2R, MTNR1A, GPR50, GPR75, OR11G2, MCHR2, MCHR1, GPR19, OR11A1, TACR1, TACR3, OR11H2, OR11H12, OR11H1, PROKR2, PROKR1, GPR88, PRLHR, OR51F1, OR10X1, NPY5R, OR9A4, NPY4R2, NPY4R |
| Tissue | amygdala, brain.meninx, cerebellum, hippocampus, middle.frontal.gyrus, middle.temporal.gyrus |
| Tissue Specificity | Highly expressed in the brain and spinal cord, and found in lower concentrations in the thymus and other tissues. {ECO:0000269|PubMed:11720708}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs3740868 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P30731}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus. {ECO:0000250|UniProtKB:P30731}. |
| Mouse PG classification | NA |
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