| Gene Information | |
|---|---|
| Gene Name | LIG4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 911 |
| Protein Names | DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000174405 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P49917 |
| Gene Card | LIG4 |
| Uniprot ID | P49917 |
| Pfam | PF00533; PF04679; PF01068; PF04675; PF11411 |
| In ASD | no |
| Allosteric Prediction | yes (0.188751003) |
| Ortholog in Animals | Alpaca_ LIG4 ( ortholog_one2one ) Dog_ LIG4 ( ortholog_one2one ) GuineaPig_ LIG4 ( ortholog_one2one ) Macaque_ LIG4 ( ortholog_one2one ) Mouse_ Lig4 ( ortholog_one2one ) Pig_ LIG4 ( ortholog_one2one ) Rat_ Lig4 ( ortholog_one2one ) Rabbit_ LIG4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LIG3, LIG1 |
| Tissue | NA |
| Tissue Specificity | Testis, thymus, prostate and heart. {ECO:0000269|PubMed:7760816}. |
| Pharmacological Animal Models | 0.018801(Chimpanzee);0.037492(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IK9 (X-ray 2.30A ) 2E2W (NMR - ) 3II6 (X-ray 2.40A ) 3VNN (X-ray 2.90A ) 3W1B (X-ray 2.40A ) 3W1G (X-ray 2.55A ) 3W5O (X-ray 2.84A ) 4HTO (X-ray 2.81A ) 4HTP (X-ray 2.25A ) 6BKF (X-ray 3.25A ) 6BKG (X-ray 2.40A ) 7D9K (X-ray 2.90A ) 7D9Y (X-ray 2.76A ) 7LSY (EM 8.40A ) 7LT3 (EM 4.60A ) 7NFC (EM 4.14A ) 7NFE (EM 4.29A ) |
| DBSNP | rs1805389 rs1805388 rs3093763 rs3093765 rs104894421 rs2232640 rs104894420 rs3742212 rs2232641 rs1060499662 rs2232642 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:24984242, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:8798671}. |
| Mouse PG classification | NA |
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