| Gene Information | |
|---|---|
| Gene Name | LIG3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1119 |
| Protein Names | Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) |
| Target Name | dna ligase 3 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000005156 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q6UXM1 |
| Gene Card | LRIG3 |
| Uniprot ID | Q6UXM1 |
| Pfam | PF07679; PF13855 |
| In ASD | no |
| Allosteric Prediction | yes (0.581385304) |
| Ortholog in Animals | Alpaca_ LIG3 ( ortholog_one2one ) Dog_ LIG3 ( ortholog_one2one ) GuineaPig_ LIG3 ( ortholog_one2one ) Macaque_ LIG3 ( ortholog_one2one ) Mouse_ Lig3 ( ortholog_one2one ) Pig_ LIG3 ( ortholog_one2one ) Rat_ Lig3 ( ortholog_one2one ) Rabbit_ LIG3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LIG1, LIG4 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:15203213}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. {ECO:0000250}. |
| Mouse PG classification | NA |
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