| Gene Information | |
|---|---|
| Gene Name | LIG3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1009 |
| Protein Names | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) |
| Target Name | dna ligase 3 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000005156 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P49916 |
| Gene Card | LIG3 |
| Uniprot ID | P49916 |
| Pfam | PF04679; PF01068; PF04675; PF16759; PF00645 |
| In ASD | no |
| Allosteric Prediction | yes (0.581385304) |
| Ortholog in Animals | Alpaca_ LIG3 ( ortholog_one2one ) Dog_ LIG3 ( ortholog_one2one ) GuineaPig_ LIG3 ( ortholog_one2one ) Macaque_ LIG3 ( ortholog_one2one ) Mouse_ Lig3 ( ortholog_one2one ) Pig_ LIG3 ( ortholog_one2one ) Rat_ Lig3 ( ortholog_one2one ) Rabbit_ LIG3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LIG1, LIG4 |
| Tissue | NA |
| Tissue Specificity | Testis, thymus, prostate and heart. |
| Pharmacological Animal Models | 0.022255(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IMO (NMR - ) 1IN1 (NMR - ) 1UW0 (NMR - ) 3L2P (X-ray 3.00A ) 3PC7 (X-ray 1.65A ) 3PC8 (X-ray 2.31A ) 3QVG (X-ray 2.26A ) 6WH1 (X-ray 2.40A ) |
| DBSNP | rs3744356 rs757797167 rs200981995 rs3136025 rs4986974 rs4986973 |
| Subcellular location [CC] | [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. Note=Contains an N-terminal mitochondrial transit peptide. {ECO:0000269|PubMed:10207110}.; [Isoform 2]: Mitochondrion {ECO:0000305|PubMed:10207110}. Note=Contains an N-terminal mitochondrial transit peptide. {ECO:0000305|PubMed:10207110}.; [Isoform 3]: Nucleus {ECO:0000269|PubMed:10207110}. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000269|PubMed:10207110}.; [Isoform 4]: Nucleus {ECO:0000305|PubMed:10207110}. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000305|PubMed:10207110}. |
| Mouse PG classification | NA |
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