| Gene Information | |
|---|---|
| Gene Name | LIG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 919 |
| Protein Names | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) |
| Target Name | dna ligase 1 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000105486 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P18858 |
| Gene Card | LIG1 |
| Uniprot ID | P18858 |
| Pfam | PF04679; PF01068; PF04675 |
| In ASD | no |
| Allosteric Prediction | yes (0.498419635) |
| Ortholog in Animals | Alpaca_ LIG1 ( ortholog_one2one ) Dog_ LIG1 ( ortholog_one2one ) Macaque_ LIG1 ( ortholog_one2one ) Mouse_ Lig1 ( ortholog_one2one ) Pig_ LIG1 ( ortholog_one2one ) Rat_ Lig1 ( ortholog_one2one ) Rabbit_ LIG1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LIG3, LIG4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.06(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1X9N (X-ray 3.00A ) 5YY9 (X-ray 2.65A ) 6P09 (X-ray 2.05A ) 6P0A (X-ray 2.05A ) 6P0B (X-ray 2.20A ) 6P0C (X-ray 1.55A ) 6P0D (X-ray 1.75A ) 6P0E (X-ray 1.85A ) 6Q1V (X-ray 1.85A ) 7KR3 (X-ray 2.78A ) 7KR4 (X-ray 2.20A ) 7L34 (X-ray 1.90A ) 7L35 (X-ray 2.00A ) 7SUM (X-ray 2.90A ) 7SX5 (X-ray 2.80A ) 7SXE (X-ray 3.00A ) |
| DBSNP | rs3730855 rs4987181 rs3730863 rs4987070 rs780748107 rs3730911 rs3730933 rs3730947 rs3730966 rs4987068 rs3730980 rs776651223 rs121434560 rs780324684 rs3731003 rs3731008 rs146309259 rs121434561 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | NA |
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