| Gene Information | |
|---|---|
| Gene Name | LIG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1093 |
| Protein Names | Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) |
| Target Name | dna ligase 1 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000105486 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q96JA1 |
| Gene Card | LRIG1 |
| Uniprot ID | Q96JA1 |
| Pfam | PF07679; PF13855; PF01463 |
| In ASD | no |
| Allosteric Prediction | yes (0.498419635) |
| Ortholog in Animals | Alpaca_ LIG1 ( ortholog_one2one ) Dog_ LIG1 ( ortholog_one2one ) Macaque_ LIG1 ( ortholog_one2one ) Mouse_ Lig1 ( ortholog_one2one ) Pig_ LIG1 ( ortholog_one2one ) Rat_ Lig1 ( ortholog_one2one ) Rabbit_ LIG1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LIG3, LIG4 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11414704}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4U7L (X-ray 2.30A ) 4U7M (X-ray 2.76A ) |
| DBSNP | rs1403626 rs2306272 rs9877201 rs332373 rs2279289 rs332374 rs2279290 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15282549}; Single-pass type I membrane protein {ECO:0000305|PubMed:15282549}. |
| Mouse PG classification | NA |
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