| Gene Information | |
|---|---|
| Gene Name | LIG |
| Organism | Homo sapiens (Human) |
| Gene Length | 200 |
| Protein Names | Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P61086 |
| Gene Card | UBE2K |
| Uniprot ID | P61086 |
| Pfam | PF00627; PF00179 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem. {ECO:0000269|PubMed:10634809, ECO:0000269|PubMed:10675012, ECO:0000269|PubMed:8702625}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.052381(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YLA (X-ray 2.40A ) 2O25 (X-ray 2.60A ) 3E46 (X-ray 1.86A ) 3F92 (X-ray 2.23A ) 3K9O (X-ray 1.80A ) 3K9P (X-ray 2.80A ) 5DFL (X-ray 2.10A ) 6IF1 (X-ray 2.47A ) 6JB6 (X-ray 2.70A ) 6JB7 (X-ray 2.10A ) 7MYF (X-ray 3.00A ) 7MYH (X-ray 2.39A ) 7OJX (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P61085}. |
| Mouse PG classification | NA |
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