| Gene Information | |
|---|---|
| Gene Name | LIFR |
| Organism | Homo sapiens (Human) |
| Gene Length | 1097 |
| Protein Names | Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) |
| Target Name | leukemia inhibitory factor receptor |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000113594 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P42702 |
| Gene Card | LIFR |
| Uniprot ID | P42702 |
| Pfam | PF00041; PF17971; PF18207 |
| In ASD | no |
| Allosteric Prediction | no (-0.198598101) |
| Ortholog in Animals | Alpaca_ LIFR ( ortholog_one2one ) Dog_ LIFR ( ortholog_one2one ) GuineaPig_ LIFR ( ortholog_one2one ) Macaque_ LIFR ( ortholog_one2one ) Mouse_ Lifr ( ortholog_one2one ) Pig_ LIFR ( ortholog_one2one ) Rat_ Lifr ( ortholog_one2one ) Rabbit_ LIFR ( ortholog_one2one ) |
| Ohnologs | IL12RB2 |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, OSMR, IL5RA, EBI3, PRLR, LEPR |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3E0G (X-ray 3.10A ) |
| DBSNP | rs3729734 rs3729740 rs2303743 rs3729744 rs3110234 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted. |
| Mouse PG classification | NA |
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