| Gene Information | |
|---|---|
| Gene Name | MAPK11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 364 |
| Protein Names | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) |
| Target Name | mitogen-activated protein kinase 11 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000185386 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15759 |
| Gene Card | MAPK11 |
| Uniprot ID | Q15759 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (1.013118797) |
| Ortholog in Animals | Alpaca_ MAPK11 ( ortholog_one2one ) GuineaPig_ MAPK11 ( ortholog_one2one ) Macaque_ MAPK11 ( ortholog_one2one ) Mouse_ Mapk11 ( ortholog_one2one ) Pig_ MAPK11 ( ortholog_one2one ) Rat_ Mapk11 ( ortholog_one2one ) |
| Ohnologs | MAPK14, MAPK13 |
| Paralogs | MAPK8, MAPK10, MAPK1, MAPK6, MAPK12, MAPK13, SRPK1, SRPK3, MAPK4, NLK, MAPK14, MAPK3, MOK, MAK, MAPK15, MAPK7, SRPK2, MAPK9, CILK1 |
| Tissue | NA |
| Tissue Specificity | Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.013150(Mouse);0.002240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3GC8 (X-ray 2.40A ) 3GC9 (X-ray 2.05A ) 3GP0 (X-ray 1.90A ) |
| DBSNP | rs33932986 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Mouse PG classification | NA |
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