| Gene Information | |
|---|---|
| Gene Name | VPS25 |
| Organism | Homo sapiens (Human) |
| Gene Length | 176 |
| Protein Names | Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000131475 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BRG1 |
| Gene Card | VPS25 |
| Uniprot ID | Q9BRG1 |
| Pfam | PF05871 |
| In ASD | no |
| Allosteric Prediction | no (-1.434798444) |
| Ortholog in Animals | Alpaca_ VPS25 ( ortholog_one2many ) Dog_ VPS25 ( ortholog_one2one ) GuineaPig_ VPS25 ( ortholog_one2one ) Macaque_ VPS25 ( ortholog_one2one ) Mouse_ Vps25 ( ortholog_one2one ) Pig_ VPS25 ( ortholog_one2one ) Rabbit_ VPS25 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of expression are found in heart, skeletal muscle, brain and lung. {ECO:0000269|PubMed:16889659}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ZME (X-ray 2.90A ) 3CUQ (X-ray 2.61A ) 3HTU (X-ray 2.00A ) |
| DBSNP | rs34494804 |
| Subcellular location [CC] | Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6. |
| Mouse PG classification | NA |
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