| Gene Information | |
|---|---|
| Gene Name | LGR4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 951 |
| Protein Names | Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) |
| Target Name | g-protein coupled receptor 48 |
| Target Type | Preclinical target |
| Gene Age | 645 ( ENSG00000205213 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BXB1 |
| Gene Card | LGR4 |
| Uniprot ID | Q9BXB1 |
| Pfam | PF00001; PF13855; PF01462 |
| In ASD | no |
| Allosteric Prediction | no (-0.980957526) |
| Ortholog in Animals | Alpaca_ LGR4 ( ortholog_one2one ) Dog_ LGR4 ( ortholog_one2one ) Macaque_ LGR4 ( ortholog_one2one ) Mouse_ Lgr4 ( ortholog_one2one ) Pig_ LGR4 ( ortholog_one2one ) Rat_ Lgr4 ( ortholog_one2one ) Rabbit_ LGR4 ( ortholog_one2one ) |
| Ohnologs | LGR5, LGR6 |
| Paralogs | LRG1, CPN2, LRRTM2, LRRC52, LRIT3, LRRC24, ELFN2, LRIG3, LGR6, LGR5, CHAD, CHADL, LRIT1, TRIL, ELFN1, LGI2, LGI1, LRIG2, LRRC26, LRIG1, LGI3, LGI4 |
| Tissue | NA |
| Tissue Specificity | Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.050650(Mouse);0.002101(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4KT1 (X-ray 2.50A ) 4QXE (X-ray 2.20A ) 4QXF (X-ray 2.25A ) |
| DBSNP | rs2448010 rs2472617 rs12284579 rs7125959 rs34717439 rs34804482 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}; Multi-pass membrane protein {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}. |
| Mouse PG classification | NA |
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