| Gene Information | |
|---|---|
| Gene Name | LGR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 764 |
| Protein Names | Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P16473 |
| Gene Card | TSHR |
| Uniprot ID | P16473 |
| Pfam | PF00001; PF13306 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in thyroide cells (at protein level) (PubMed:11847099). Expressed in the thyroid (PubMed:2610690). {ECO:0000269|PubMed:11847099, ECO:0000269|PubMed:2610690}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XWT (X-ray 1.90A ) 3G04 (X-ray 2.55A ) 7XW5 (EM 2.96A ) 7XW6 (EM 2.78A ) 7XW7 (EM 5.50A ) |
| DBSNP | rs45499704 rs61747482 rs2234919 rs121908863 rs28937584 rs1991517 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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