| Gene Information | |
|---|---|
| Gene Name | LGMN |
| Organism | Homo sapiens (Human) |
| Gene Length | 433 |
| Protein Names | Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1) |
| Target Name | legumain |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000100600 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99538 |
| Gene Card | LGMN |
| Uniprot ID | Q99538 |
| Pfam | PF01650 |
| In ASD | yes |
| Allosteric Prediction | yes (0.655914877) |
| Ortholog in Animals | Alpaca_ LGMN ( ortholog_one2one ) Dog_ LGMN ( ortholog_one2one ) GuineaPig_ LGMN ( ortholog_one2one ) Macaque_ LGMN ( ortholog_one2one ) Mouse_ Lgmn ( ortholog_one2one ) Pig_ LGMN ( ortholog_one2one ) Rat_ Lgmn ( ortholog_one2one ) Rabbit_ LGMN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PIGK |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Particularly abundant in kidney, heart and placenta. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001899(Rat);0.030769(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4AW9 (X-ray 2.20A ) 4AWA (X-ray 2.50A ) 4AWB (X-ray 2.70A ) 4FGU (X-ray 3.90A ) 4N6N (X-ray 1.87A ) 4N6O (X-ray 1.80A ) 5LU8 (X-ray 1.95A ) 5LU9 (X-ray 2.27A ) 5LUA (X-ray 2.00A ) 5LUB (X-ray 2.10A ) 7O50 (X-ray 1.90A ) |
| DBSNP | rs2236264 |
| Subcellular location [CC] | Lysosome {ECO:0000250}. |
| Mouse PG classification | NA |
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