| Gene Information | |
|---|---|
| Gene Name | LFR |
| Organism | Homo sapiens (Human) |
| Gene Length | 313 |
| Protein Names | Intelectin-1 (ITLN-1) (Endothelial lectin HL-1) (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (Omentin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8WWA0 |
| Gene Card | ITLN1 |
| Uniprot ID | Q8WWA0 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level) (PubMed:16531507). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus. {ECO:0000269|PubMed:11181563, ECO:0000269|PubMed:11313366, ECO:0000269|PubMed:11747454, ECO:0000269|PubMed:16531507}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4WMQ (X-ray 1.80A ) 4WMY (X-ray 1.60A ) 6USC (X-ray 1.59A ) |
| DBSNP | rs2274907 rs8144 |
| Subcellular location [CC] | Cell membrane {ECO:0000305|PubMed:11747454}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:11747454}. Secreted {ECO:0000269|PubMed:11313366, ECO:0000269|PubMed:16531507, ECO:0000305|PubMed:11747454}. Note=Enriched in lipid rafts. {ECO:0000250|UniProtKB:O88310}. |
| Mouse PG classification | NA |
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