| Gene Information | |
|---|---|
| Gene Name | LETMD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 360 |
| Protein Names | LETM1 domain-containing protein 1 (Cervical cancer 1 proto-oncogene protein p40) (Cervical cancer proto-oncogene 2 protein) (HCCR-1) (HCRR-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000050426 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6P1Q0 |
| Gene Card | LETMD1 |
| Uniprot ID | Q6P1Q0 |
| Pfam | PF07766 |
| In ASD | no |
| Allosteric Prediction | no (-1.217888837) |
| Ortholog in Animals | Alpaca_ LETMD1 ( ortholog_one2one ) Dog_ LETMD1 ( ortholog_one2one ) GuineaPig_ LETMD1 ( ortholog_one2one ) Macaque_ LETMD1 ( ortholog_one2one ) Mouse_ Letmd1 ( ortholog_one2one ) Pig_ LETMD1 ( ortholog_one2one ) Rat_ Letmd1 ( ortholog_one2one ) Rabbit_ LETMD1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LETM1, LETM2 |
| Tissue | NA |
| Tissue Specificity | Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix. {ECO:0000269|PubMed:12879013}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12379 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:17943721, ECO:0000269|PubMed:18045496}; Single-pass membrane protein {ECO:0000269|PubMed:18045496}. |
| Mouse PG classification | NA |
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