| Gene Information | |
|---|---|
| Gene Name | LETAL |
| Organism | Homo sapiens (Human) |
| Gene Length | 263 |
| Protein Names | Retinoic acid early transcript 1E (Lymphocyte effector toxicity activation ligand) (NKG2D ligand 4) (N2DL-4) (NKG2DL4) (RAE-1-like transcript 4) (UL16-binding protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8TD07 |
| Gene Card | RAET1E |
| Uniprot ID | Q8TD07 |
| Pfam | PF00129 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid. {ECO:0000269|PubMed:12732206, ECO:0000269|PubMed:14508119}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9383583 rs2151910 rs6925151 rs9383921 rs9371533 rs57292884 rs2342767 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:15240696}; Single-pass type I membrane protein.; [Isoform 4]: Secreted. |
| Mouse PG classification | NA |
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